Advances in Development of New Treatment for Leishmaniasis
Joint Authors
de Menezes, Juliana Perrone Bezerra
Guedes, Carlos Eduardo Sampaio
Petersen, Antônio Luis de Oliveira Almeida
Fraga, Deborah Bittencourt Mothé
Veras, Patrícia Sampaio Tavares
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania.
Current strategies to control this disease are mainly based on chemotherapy.
Despite being available for the last 70 years, leishmanial chemotherapy has lack of efficiency, since its route of administration is difficult and it can cause serious side effects, which results in the emergence of resistant cases.
The medical-scientific community is facing difficulties to overcome these problems with new suitable and efficient drugs, as well as the identification of new drug targets.
The availability of the complete genome sequence of Leishmania has given the scientific community the possibility of large-scale analysis, which may lead to better understanding of parasite biology and consequent identification of novel drug targets.
In this review we focus on how high-throughput analysis is helping us and other groups to identify novel targets for chemotherapeutic interventions.
We further discuss recent data produced by our group regarding the use of the high-throughput techniques and how this helped us to identify and assess the potential of new identified targets.
American Psychological Association (APA)
de Menezes, Juliana Perrone Bezerra& Guedes, Carlos Eduardo Sampaio& Petersen, Antônio Luis de Oliveira Almeida& Fraga, Deborah Bittencourt Mothé& Veras, Patrícia Sampaio Tavares. 2015. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056834
Modern Language Association (MLA)
de Menezes, Juliana Perrone Bezerra…[et al.]. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056834
American Medical Association (AMA)
de Menezes, Juliana Perrone Bezerra& Guedes, Carlos Eduardo Sampaio& Petersen, Antônio Luis de Oliveira Almeida& Fraga, Deborah Bittencourt Mothé& Veras, Patrícia Sampaio Tavares. Advances in Development of New Treatment for Leishmaniasis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056834