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Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?
Joint Authors
Silva Júnior, Wellington Santana da
Godoy-Matos, Amélio Fernando de
Kraemer-Aguiar, Luiz Guilherme
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) has become one of the most prevalent noncommunicable diseases in the past years.
It is undoubtedly associated with atherosclerosis and increased risk for cardiovascular diseases.
Incretins, which are intestinal peptides secreted during digestion, are able to increase insulin secretion and its impaired function and/or secretion is involved in the pathophysiology of T2DM.
Dipeptidyl peptidase 4 (DPP4) is an ubiquitous enzyme that regulates incretins and consequently is related to the pathophysiology of T2DM.
DPP4 is mainly secreted by endothelial cells and acts as a regulatory protease for cytokines, chemokines, and neuropeptides involved in inflammation, immunity, and vascular function.
In T2DM, the activity of DPP4 seems to be increased and there are a growing number of in vitro and in vivo studies suggesting that this enzyme could be a new link between T2DM and atherosclerosis.
Gliptins are a new class of pharmaceutical agents that acts by inhibiting DPP4.
Thus, it is expected that gliptin represents a new pharmacological approach not only for reducing glycemic levels in T2DM, but also for the prevention and treatment of atherosclerotic cardiovascular disease in diabetic subjects.
We aimed to review the evidences that reinforce the associations between DPP4, atherosclerosis, and T2DM.
American Psychological Association (APA)
Silva Júnior, Wellington Santana da& Godoy-Matos, Amélio Fernando de& Kraemer-Aguiar, Luiz Guilherme. 2015. Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056841
Modern Language Association (MLA)
Silva Júnior, Wellington Santana da…[et al.]. Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056841
American Medical Association (AMA)
Silva Júnior, Wellington Santana da& Godoy-Matos, Amélio Fernando de& Kraemer-Aguiar, Luiz Guilherme. Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056841