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Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study
Joint Authors
Alpayci, Mahmut
Delen, Veysel
Aydin, Mehmet Nuri
Guducuoglu, Huseyin
Bayram, Yasemin
Milanlıoğlu, Aysel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS).
Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA).
The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls.
Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study.
The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA).
The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls ( P < 0.001 ) .
Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls.
Also, no significant correlation was found between the anti-CCP levels and EDSS scores ( r = - 0.250 ) .
In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.
American Psychological Association (APA)
Alpayci, Mahmut& Milanlıoğlu, Aysel& Delen, Veysel& Aydin, Mehmet Nuri& Guducuoglu, Huseyin& Bayram, Yasemin. 2015. Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056846
Modern Language Association (MLA)
Alpayci, Mahmut…[et al.]. Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1056846
American Medical Association (AMA)
Alpayci, Mahmut& Milanlıoğlu, Aysel& Delen, Veysel& Aydin, Mehmet Nuri& Guducuoglu, Huseyin& Bayram, Yasemin. Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1056846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056846