Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro
Joint Authors
Moyo, Batanai
Mukanganyama, Stanley
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Triumfetta welwitschii is a plant used traditionally for the treatment of fever and diarrhoea.
Previous work has shown that T.
welwitschii has antibacterial activity.
The purpose of this study was to investigate T.
welwitschii extract for anticancer activity against Jurkat T cells.
The Jurkat T cell line is used to study acute T cell leukaemia.
An antiproliferation assay, determination of induction of apoptosis, the determination of the effect of the combination of the extract and GSH, and effects of the extract on DNA leakage were conducted.
T.
welwitschii was found to decrease cell viability in a dose- and time-dependent manner.
T.
welwitschii caused apoptosis in the Jurkat T cells as shown by DNA fragmentation.
When T.
welwitschii was combined with reduced GSH, it was found that the growth of the Jurkat T cells was significantly reduced compared to untreated cells after 72 h of treatment.
This was unexpected, as cancer cells have elevated levels of GSH compared to normal cells.
The results of this study show that T.
welwitschii is a potential source of compounds that may serve as leads for anticancer compounds.
American Psychological Association (APA)
Moyo, Batanai& Mukanganyama, Stanley. 2015. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056849
Modern Language Association (MLA)
Moyo, Batanai& Mukanganyama, Stanley. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056849
American Medical Association (AMA)
Moyo, Batanai& Mukanganyama, Stanley. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056849