Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro

Joint Authors

Moyo, Batanai
Mukanganyama, Stanley

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-10-18

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Triumfetta welwitschii is a plant used traditionally for the treatment of fever and diarrhoea.

Previous work has shown that T.

welwitschii has antibacterial activity.

The purpose of this study was to investigate T.

welwitschii extract for anticancer activity against Jurkat T cells.

The Jurkat T cell line is used to study acute T cell leukaemia.

An antiproliferation assay, determination of induction of apoptosis, the determination of the effect of the combination of the extract and GSH, and effects of the extract on DNA leakage were conducted.

T.

welwitschii was found to decrease cell viability in a dose- and time-dependent manner.

T.

welwitschii caused apoptosis in the Jurkat T cells as shown by DNA fragmentation.

When T.

welwitschii was combined with reduced GSH, it was found that the growth of the Jurkat T cells was significantly reduced compared to untreated cells after 72 h of treatment.

This was unexpected, as cancer cells have elevated levels of GSH compared to normal cells.

The results of this study show that T.

welwitschii is a potential source of compounds that may serve as leads for anticancer compounds.

American Psychological Association (APA)

Moyo, Batanai& Mukanganyama, Stanley. 2015. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056849

Modern Language Association (MLA)

Moyo, Batanai& Mukanganyama, Stanley. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056849

American Medical Association (AMA)

Moyo, Batanai& Mukanganyama, Stanley. Antiproliferative Activity of T. welwitschii Extract on Jurkat T Cells In Vitro. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056849

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056849