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Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A BattleQuest for Iron
Joint Authors
De Baetselier, Patrick
Magez, Stefan
Stijlemans, Benoit
Beschin, Alain
Van Ginderachter, Jo A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
African trypanosomosis is a chronic debilitating disease affecting the health and economic well-being of developing countries.
The immune response during African trypanosome infection consisting of a strong proinflammatory M1-type activation of the myeloid phagocyte system (MYPS) results in iron deprivation for these extracellular parasites.
Yet, the persistence of M1-type MYPS activation causes the development of anemia (anemia of chronic disease, ACD) as a most prominent pathological parameter in the mammalian host, due to enhanced erythrophagocytosis and retention of iron within the MYPS thereby depriving iron for erythropoiesis.
In this review we give an overview of how parasites acquire iron from the host and how iron modulation of the host MYPS affects trypanosomosis-associated anemia development.
Finally, we also discuss different strategies at the level of both the host and the parasite that can/might be used to modulate iron availability during African trypanosome infections.
American Psychological Association (APA)
Stijlemans, Benoit& Beschin, Alain& Magez, Stefan& Van Ginderachter, Jo A.& De Baetselier, Patrick. 2015. Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A BattleQuest for Iron. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056856
Modern Language Association (MLA)
Stijlemans, Benoit…[et al.]. Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A BattleQuest for Iron. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056856
American Medical Association (AMA)
Stijlemans, Benoit& Beschin, Alain& Magez, Stefan& Van Ginderachter, Jo A.& De Baetselier, Patrick. Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A BattleQuest for Iron. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056856