![](/images/graphics-bg.png)
Role of Extracellular Vesicles in Hematological Malignancies
Joint Authors
Alessandro, Riccardo
Raimondo, Stefania
Corrado, Chiara
Raimondi, Lavinia
De Leo, Giacomo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized.
Recent studies have focused on how cancer cells communicate within the microenvironment.
Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types.
EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis.
Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies.
Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery.
Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies.
American Psychological Association (APA)
Raimondo, Stefania& Corrado, Chiara& Raimondi, Lavinia& De Leo, Giacomo& Alessandro, Riccardo. 2015. Role of Extracellular Vesicles in Hematological Malignancies. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056864
Modern Language Association (MLA)
Raimondo, Stefania…[et al.]. Role of Extracellular Vesicles in Hematological Malignancies. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056864
American Medical Association (AMA)
Raimondo, Stefania& Corrado, Chiara& Raimondi, Lavinia& De Leo, Giacomo& Alessandro, Riccardo. Role of Extracellular Vesicles in Hematological Malignancies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056864