In Vitro Inhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-Resistant Staphylococcus aureus Clinical Isolates
Joint Authors
Shaameri, Zurina
Hamzah, Ahmad Sazali
Johari, Saiful Azmi
Mohtar, Mastura
Syed Mohammad, Sharifah Aminah
Sahdan, Rohana
Mohammat, Mohd Fazli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S.
aureus isolates.
One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15.6 to 31.3 μg/mL against 55 S.
aureus isolates (43 MRSA and 12 MSSA isolates).
The active compound also displayed MBC values between 250 and 500 μg/mL against 58 S.
aureus isolates (45 MRSA and 13 MSSA isolates) implying that MFM 501 has a bacteriostatic rather than bactericidal effect against both MRSA and MSSA isolates.
In addition, MFM 501 showed no apparent cytotoxicity activity towards three normal cell lines (WRL-68, Vero, and 3T3) with IC50 values of >625 µg/mL.
Selectivity index (SI) of MFM 501 gave a value of >10 suggesting that MFM 501 is significant and suitable for further in vivo investigations.
These results suggested that synthetically derived intermediate compounds based on natural products may play an important role in the discovery of new anti-infective agents against MRSA.
American Psychological Association (APA)
Johari, Saiful Azmi& Mohtar, Mastura& Syed Mohammad, Sharifah Aminah& Sahdan, Rohana& Shaameri, Zurina& Hamzah, Ahmad Sazali…[et al.]. 2015. In Vitro Inhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-Resistant Staphylococcus aureus Clinical Isolates. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056874
Modern Language Association (MLA)
Johari, Saiful Azmi…[et al.]. In Vitro Inhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-Resistant Staphylococcus aureus Clinical Isolates. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056874
American Medical Association (AMA)
Johari, Saiful Azmi& Mohtar, Mastura& Syed Mohammad, Sharifah Aminah& Sahdan, Rohana& Shaameri, Zurina& Hamzah, Ahmad Sazali…[et al.]. In Vitro Inhibitory and Cytotoxic Activity of MFM 501, a Novel Codonopsinine Derivative, against Methicillin-Resistant Staphylococcus aureus Clinical Isolates. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056874