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Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity
Joint Authors
Couture, Frédéric
Ly, Kévin
Levesque, Christine
Kwiatkowska, Anna
Ait-Mohand, Samia
Desjardins, Roxane
Guérin, Brigitte
Day, Robert
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The overexpression as well as the critical implication of the proprotein convertase PACE4 in prostate cancer progression has been previously reported and supported the development of peptide inhibitors.
The multi-Leu peptide, a PACE4-specific inhibitor, was further generated and its capability to be uptaken by tumor xenograft was demonstrated with regard to its PACE4 expression status.
To investigate whether the uptake of this inhibitor was directly dependent of PACE4 levels, uptake and efflux from cancer cells were evaluated and correlations were established with PACE4 contents on both wild type and PACE4-knockdown cell lines.
PACE4-knockdown associated growth deficiencies were established on the knockdown HepG2, Huh7, and HT1080 cells as well as the antiproliferative effects of the multi-Leu peptide supporting the growth capabilities of PACE4 in cancer cells.
American Psychological Association (APA)
Couture, Frédéric& Ly, Kévin& Levesque, Christine& Kwiatkowska, Anna& Ait-Mohand, Samia& Desjardins, Roxane…[et al.]. 2015. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056876
Modern Language Association (MLA)
Couture, Frédéric…[et al.]. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056876
American Medical Association (AMA)
Couture, Frédéric& Ly, Kévin& Levesque, Christine& Kwiatkowska, Anna& Ait-Mohand, Samia& Desjardins, Roxane…[et al.]. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056876