Mosaicism of Mitochondrial Genetic Variation in Atherosclerotic Lesions of the Human Aorta
Joint Authors
Sazonova, Margarita A.
Bobryshev, Yuri V.
Sinyov, Vasily V.
Barinova, Valeria A.
Ryzhkova, Anastasia I.
Zhelankin, Andrey V.
Postnov, Anton Y.
Orekhov, Alexander N.
Sobenin, Igor A.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of the present study was an analysis of heteroplasmy level in mitochondrial mutations 652delG, A1555G, C3256T, T3336C, 652insG, C5178A, G12315A, G13513A, G14459A, G14846A, and G15059A in normal and affected by atherosclerosis segments of morphologically mapped aortic walls.
Methods.
We investigated the 265 normal and atherosclerotic tissue sections of 5 human aortas.
Intima of every aorta was divided according to morphological characteristics into segments with different types of atherosclerotic lesions: fibrous plaque, lipofibrous plaque, primary atherosclerotic lesion (fatty streak and fatty infiltration), and normal intima from human aorta.
PCR-fragments were analyzed by a new original method developed in our laboratory on the basis of pyrosequence technology.
Results.
According to the obtained data, mutations G12315A and G14459A are significantly associated with total and primary atherosclerotic lesions of intimal segments and lipofibrous plaques ( P ≤ 0.01 and P ≤ 0.05 , accordingly).
Mutation C5178A is significantly associated with fibrous plaques and total atherosclerotic lesions ( P ≤ 0.01 ) .
A1555G mutation shows an antiatherosclerotic effect in primary lesion in lipofibrous plaques ( P ≤ 0.05 ) .
Meanwhile, G14846A mutation is antiatherogenic for lipofibrous plaques ( P ≤ 0.05 ) .
Conclusion.
Therefore, mutations C5178A, G14459A, G12315A, A1555G, and G14846A were found to be associated with atherosclerotic lesions.
American Psychological Association (APA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Barinova, Valeria A.& Ryzhkova, Anastasia I.& Zhelankin, Andrey V.& Postnov, Anton Y.…[et al.]. 2015. Mosaicism of Mitochondrial Genetic Variation in Atherosclerotic Lesions of the Human Aorta. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056890
Modern Language Association (MLA)
Sazonova, Margarita A.…[et al.]. Mosaicism of Mitochondrial Genetic Variation in Atherosclerotic Lesions of the Human Aorta. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056890
American Medical Association (AMA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Barinova, Valeria A.& Ryzhkova, Anastasia I.& Zhelankin, Andrey V.& Postnov, Anton Y.…[et al.]. Mosaicism of Mitochondrial Genetic Variation in Atherosclerotic Lesions of the Human Aorta. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056890