Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis
Joint Authors
Assinder, Stephen J.
Beniamen, Daniella
Lovicu, Frank J.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Deregulation of FGF receptor tyrosine kinase (RTK) signalling is common in prostate cancer.
Normally, to moderate RTK signalling, induction of Sprouty (SPRY) and Sprouty-related (SPRED) antagonists occurs.
Whilst decreased SPRY and SPRED has been described in some cancers, their role in prostate cancer is poorly understood.
Therefore, we hypothesise that due to the need for tight regulation of RTK signalling, SPRY and SPRED negative regulators provide a degree of redundancy which ensures that a suppression of one or more family member does not lead to disease.
Contrary to this, our analyses of prostates from 24-week-old Spry1- or Spry2-deficientmice, either hemizygous (+/−) or homozygous (−/−) for the null allele, revealed a significantly greater incidence of PIN compared to wild-type littermates.
We further investigated redundancy of negative regulators in the clinical setting in a preliminary analysis of Gene Expression Omnibus and Oncomine human prostate cancer datasets.
Consistent with our hypothesis, in two datasets analysed a significant cosuppression of SPRYs and SPREDs is evident.
These findings demonstrate the importance of negative regulators of receptor tyrosine signalling, such as Spry, in the clinical setting, and highlight their importance for future pharmacopeia.
American Psychological Association (APA)
Assinder, Stephen J.& Beniamen, Daniella& Lovicu, Frank J.. 2015. Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056893
Modern Language Association (MLA)
Assinder, Stephen J.…[et al.]. Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056893
American Medical Association (AMA)
Assinder, Stephen J.& Beniamen, Daniella& Lovicu, Frank J.. Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056893