Clinical End-Points Associated with Mycobacteriumtuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution
Joint Authors
Tian, Yansheng
Hao, Tong
Cao, Bin
Zhang, Wei
Ma, Yan
Lin, Qiang
Li, Xiaomin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is a recent emerging theory that suggests a cross-link between pathogens and cancer.
In this context, we examined the association between the Mycobacterium tuberculosis (MTB) with its L-forms (MTB-L) and lung cancer.
In the present study, we have optimized and applied a highly sensitive assay to detect the presence of MTB and MTB-L in 187 lung cancer samples and 39 samples of other cancer origins.
By carefully controlling confounding factors, we have found that 62% of the lung cancer samples are MTB-L positive, while only 5.1% of the other cancer samples are MTB-L positive.
Through generalized linear models and random forest models, we have further identified a set of clinical end-points that are strongly associated with MTB-L presence.
Our finding provides the basis for future studies to investigate the underlying mechanism linking MTB-L infection to lung cancer development.
American Psychological Association (APA)
Tian, Yansheng& Hao, Tong& Cao, Bin& Zhang, Wei& Ma, Yan& Lin, Qiang…[et al.]. 2015. Clinical End-Points Associated with Mycobacteriumtuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056896
Modern Language Association (MLA)
Tian, Yansheng…[et al.]. Clinical End-Points Associated with Mycobacteriumtuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056896
American Medical Association (AMA)
Tian, Yansheng& Hao, Tong& Cao, Bin& Zhang, Wei& Ma, Yan& Lin, Qiang…[et al.]. Clinical End-Points Associated with Mycobacteriumtuberculosis and Lung Cancer: Implications into Host-Pathogen Interaction and Coevolution. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056896