Inhibitory Effect of Various Breads on DMH-Induced Aberrant Crypt Foci and Colorectal Tumours in Rats

Joint Authors

Qi, Guangying
Zeng, Sien
Takashima, Tiri
Nozoe, Koichiro
Shobayashi, Megumi
Kakugawa, Koji
Murakami, Kaori
Jikihara, Hiroshi
Zhou, Lihua
Shimamoto, Fumio

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-14

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Bread is rich in dietary fibre and many phytochemical compounds, which may influence chemoprevention of colon cancer.

In the present study, we evaluated the effect of three kinds of bread on DMH-induced colorectal tumours in F344 rats.

F344 rats were divided into four groups (Steinmetz Three-Grain bread, Steinmetz Country bread, White bread, and MF).

All groups were injected with 1,2-dimethylhydrazine (DMH, 20 mg/kg body weight) once a week for 8 consecutive weeks from 5 weeks of age.

To investigate the antioxidant effect of bread, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging rate of bread and the serum levels of 8-hydroxy-deoxyguanosine (8-OHdG) in rats were examined.

The number of colorectal aberrant crypt foci (ACF) and the incidence of colorectal tumours were studied after 34 weeks of DMH treatment.

The Steinmetz Three-Grain and Steinmetz Country bread groups had higher scavenging rates of the DPPH free radical and lower serum levels of 8-OHdG and incidence of ACF, adenomas, and adenocarcinomas of colon than the White bread and MF group.

Steinmetz Three-Grain bread and Steinmetz Country bread have various ingredient combinations that may inhibit colorectal cancer progression.

American Psychological Association (APA)

Qi, Guangying& Zeng, Sien& Takashima, Tiri& Nozoe, Koichiro& Shobayashi, Megumi& Kakugawa, Koji…[et al.]. 2015. Inhibitory Effect of Various Breads on DMH-Induced Aberrant Crypt Foci and Colorectal Tumours in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056901

Modern Language Association (MLA)

Qi, Guangying…[et al.]. Inhibitory Effect of Various Breads on DMH-Induced Aberrant Crypt Foci and Colorectal Tumours in Rats. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056901

American Medical Association (AMA)

Qi, Guangying& Zeng, Sien& Takashima, Tiri& Nozoe, Koichiro& Shobayashi, Megumi& Kakugawa, Koji…[et al.]. Inhibitory Effect of Various Breads on DMH-Induced Aberrant Crypt Foci and Colorectal Tumours in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056901

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056901