COMT-by-Sex Interaction Effect on Psychosis Proneness
Joint Authors
de Castro-Catala, Marta
Barrantes-Vidal, Neus
Sheinbaum, Tamara
Moreno-Fortuny, Artal
Kwapil, Thomas R.
Rosa, Araceli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Schizotypy phenotypes in the general population share etiopathogenic mechanisms and risk factors with schizophrenia, supporting the notion of psychosis as a continuum ranging from nonclinical to clinical deviance.
Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex.
Several recent studies have reported a sex difference in the impact of COMT genotype on psychiatric and cognitive phenotypes and personality traits.
The present study investigated the association of COMT Val158Met (rs4680) with psychometric positive and negative schizotypy and psychotic experiences in a sample of 808 nonclinical young adults.
The main finding was that sex moderates the association of COMT genotype with the negative dimension of both schizotypy and psychotic experiences.
Male subjects carrying the Val allele tended to score higher on the negative dimension of both trait and symptom-like measures.
The results from the present study are consistent with recent work suggesting an association between negative schizotypy and diminished prefrontal dopamine availability.
They support the idea that a biological differentiation underlies the positive and negative schizotypy dimensions.
Additionally, these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
American Psychological Association (APA)
de Castro-Catala, Marta& Barrantes-Vidal, Neus& Sheinbaum, Tamara& Moreno-Fortuny, Artal& Kwapil, Thomas R.& Rosa, Araceli. 2015. COMT-by-Sex Interaction Effect on Psychosis Proneness. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056902
Modern Language Association (MLA)
de Castro-Catala, Marta…[et al.]. COMT-by-Sex Interaction Effect on Psychosis Proneness. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056902
American Medical Association (AMA)
de Castro-Catala, Marta& Barrantes-Vidal, Neus& Sheinbaum, Tamara& Moreno-Fortuny, Artal& Kwapil, Thomas R.& Rosa, Araceli. COMT-by-Sex Interaction Effect on Psychosis Proneness. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056902