Crocetin Downregulates the Proinflammatory Cytokines in Methylcholanthrene-Induced Rodent Tumor Model and Inhibits COX-2 Expression in Cervical Cancer Cells
Joint Authors
Chen, Bing
Hou, Zhao-Hui
Dong, Zhe
Li, Chun-Dong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The effect of crocetin (C20H24O4) on methylcholanthrene- (MCA-) induced uterine cervical cancer in mice was studied in this paper.
After the mice were treated orally with crocetin, maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were examined by ELISA or immunohistochemistry.
The inducible nitric oxide synthase (iNOS) activation in HeLa cells was analyzed using fluorescence microscopy for light microscopic examination.
The MCA mice showed a significant increase in plasma MDA, PMN, IL-1β, TNF-α, and nitrates levels.
At the same time, the mRNA level of COX-2 in HeLa cells was also significantly increased.
These changes were attenuated by crocetin supplementation in the MCA mice.
Crocetin supplementation in the MCA mice also showed protection against cervical cancer.
These results suggest that crocetin may act as a chemopreventive and an anti-inflammatory agent.
American Psychological Association (APA)
Chen, Bing& Hou, Zhao-Hui& Dong, Zhe& Li, Chun-Dong. 2015. Crocetin Downregulates the Proinflammatory Cytokines in Methylcholanthrene-Induced Rodent Tumor Model and Inhibits COX-2 Expression in Cervical Cancer Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056904
Modern Language Association (MLA)
Chen, Bing…[et al.]. Crocetin Downregulates the Proinflammatory Cytokines in Methylcholanthrene-Induced Rodent Tumor Model and Inhibits COX-2 Expression in Cervical Cancer Cells. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056904
American Medical Association (AMA)
Chen, Bing& Hou, Zhao-Hui& Dong, Zhe& Li, Chun-Dong. Crocetin Downregulates the Proinflammatory Cytokines in Methylcholanthrene-Induced Rodent Tumor Model and Inhibits COX-2 Expression in Cervical Cancer Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056904