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The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence
Joint Authors
Uchida, Tomohisa
Trang, Tran Thi Huyen
Matsuda, Miyuki
Binh, Tran Thanh
Suzuki, Rumiko
Vilaichone, Ratha-korn
Mahachai, Varocha
Tshering, Lotay
Dung, Ho D. Q.
Matsunari, Osamu
Myint, Thein
Khien, Vu Van
Yamaoka, Yoshio
Shiota, Seiji
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gastric cancer is a significant health problem in Asia.
Although the prevalence of Helicobacter pylori infection is similar in Bhutan, Vietnam, and Myanmar, the incidence of gastric cancer is highest in Bhutan, followed by Vietnam and Myanmar.
We hypothesized that H.
pylori virulence factors contribute to the differences.
The status of cagA, vacA, jhp0562, and β-(1,3)galT(jhp0563) was examined in 371 H.
pylori-infected patients from Bhutan, Vietnam, and Myanmar.
Each virulence factor could not explain the difference of the incidence of gastric cancer.
However, the prevalence of quadruple-positive for cagA, vacA s1, vacA m1, and jhp0562-positive/β-(1,3)galT-negative was significantly higher in Bhutan than in Vietnam and Myanmar and correlated with gastric cancer incidence.
Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruple-positive strains.
We suggest that the cagA, vacA s1, vacA m1, and jhp0562-positive/β-(1,3)galT-negative genotype may play a role in the development of gastric cancer.
American Psychological Association (APA)
Trang, Tran Thi Huyen& Shiota, Seiji& Matsuda, Miyuki& Binh, Tran Thanh& Suzuki, Rumiko& Vilaichone, Ratha-korn…[et al.]. 2015. The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056908
Modern Language Association (MLA)
Trang, Tran Thi Huyen…[et al.]. The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056908
American Medical Association (AMA)
Trang, Tran Thi Huyen& Shiota, Seiji& Matsuda, Miyuki& Binh, Tran Thanh& Suzuki, Rumiko& Vilaichone, Ratha-korn…[et al.]. The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056908