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Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.
Joint Authors
Ku, Nam Su
Chung, Hae-Sun
Choi, Jun Yong
Lee, Kyungwon
Kim, June Myung
Chong, Yunsop
Yong, Dongeun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated the clinical usefulness of the revised 2010 Clinical and Laboratory Standards Institute (CLSI) breakpoints for Escherichia coli and Klebsiella spp.
Of 2,623 patients with bacteremia caused by E.
coli or Klebsiella spp., 573 who had been treated appropriately with cephalosporin based on the CLSI 2009 guidelines were enrolled.
There were no differences in the rates of treatment failure or mortality between the appropriately and inappropriately treated groups according to the CLSI 2010 guidelines.
Additionally, in the matched case-control analysis, the treatment failure rate was higher in bacteremic patients with extended-spectrum β-lactamase- (ESBL-) producing but cephalosporin-susceptible organisms than in those with ESBL-nonproducing isolates when patients with urinary tract infections were excluded (44% and 0%, resp., P = 0.026 ).
In patients with bacteremia caused by E.
coli or Klebsiella spp., the revised CLSI 2010 guidelines did not lead to poorer outcomes.
However, ESBL production appeared to be associated with poor clinical outcomes in patients with bacteremia from sources other than the urinary tract.
American Psychological Association (APA)
Ku, Nam Su& Chung, Hae-Sun& Choi, Jun Yong& Yong, Dongeun& Lee, Kyungwon& Kim, June Myung…[et al.]. 2015. Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056911
Modern Language Association (MLA)
Ku, Nam Su…[et al.]. Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056911
American Medical Association (AMA)
Ku, Nam Su& Chung, Hae-Sun& Choi, Jun Yong& Yong, Dongeun& Lee, Kyungwon& Kim, June Myung…[et al.]. Clinical Usefulness of the 2010 Clinical and Laboratory Standards Institute Revised Breakpoints for Cephalosporin Use in the Treatment of Bacteremia Caused by Escherichia coli or Klebsiella spp.. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056911