The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The pathophysiology of posttraumatic syringomyelia is incompletely understood.
We examined whether local ischemia occurs after spinal cord injury.
If so, whether it causes neuronal mitochondrial dysfunction and depletion, and subsequent energy metabolism impairment results in cell starvation of energy and even cell death, contributing to the enlargement of the cavity.
Local blood flow was measured in a rat model of posttraumatic syringomyelia that had received injections of quisqualic acid and kaolin.
We found an 86±11% reduction of local blood flow at C8 where a cyst formed at 6 weeks after syrinx induction procedure (P<0.05), and no difference in blood flow rate between the laminectomy and intact controls.
Electron microscopy confirmed irreversible neuronal mitochondrion depletion surrounding the cyst, but recoverable mitochondrial loses in laminectomy rats.
Profound energy loss quantified in the spinal cord of syrinx animals, and less ATP and ADP decline observed in laminectomy rats.
Our findings demonstrate that an excitotoxic injury induces local ischemia in the spinal cord and results in neuronal mitochondrial depletion, and profound ATP loss, contributing to syrinx enlargement.
Ischemia did not occur following laminectomy induced trauma in which mitochondrial loss and decline in ATP were reversible.
This confirms excitotoxic injury contributing to the pathology of posttraumatic syringomyelia.
American Psychological Association (APA)
Hu, Zhiqiang& Tu, Jian. 2015. The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056915
Modern Language Association (MLA)
Hu, Zhiqiang& Tu, Jian. The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056915
American Medical Association (AMA)
Hu, Zhiqiang& Tu, Jian. The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056915