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Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model
Joint Authors
Fang, Wen
Zhao, Shifang
He, Fuming
Liu, Li
Yang, Guoli
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone.
This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis.
In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats.
After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation.
The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces.
In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats.
Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
American Psychological Association (APA)
Fang, Wen& Zhao, Shifang& He, Fuming& Liu, Li& Yang, Guoli. 2015. Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056916
Modern Language Association (MLA)
Fang, Wen…[et al.]. Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1056916
American Medical Association (AMA)
Fang, Wen& Zhao, Shifang& He, Fuming& Liu, Li& Yang, Guoli. Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1056916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056916