Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases

Abstract EN

Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous which present a wide spectrum of pathological and clinical manifestations.

Fourteen patients with histologically demonstrated LNEC were collected and analyzed retrospectively.

The 14 cases were classified into 3 subtypes: typical carcinoid in 2, atypical carcinoid in 5, and small cell neuroendocrine carcinoma in 7.

The mean survival time of the 14 patients in this study was 112.5 months (95% CI, 81.5–143.6).

Surgeries were performed for 2 patients of typical carcinoid, and they were alive with no evidence of recurrence after 24 and 47 months of follow-ups.

Patients in the atypical carcinoid group were treated with surgeries and postoperative radiotherapy.

After 58.4 months of follow-ups (range: 9–144), 2 patients showed no evidence of disease and 1 was lost to follow-up after 72 months.

The other 2 patients died of other unrelated diseases.

In the small cell neuroendocrine carcinoma group, a combination of chemotherapy and radiotherapy was applied.

The mean survival time was 79.7 months (95% CI, 37.9–121.4), and the 5-year survival rate was 53.6%.

In conclusion, the clinical behaviors, treatment protocols, and prognosis are different for each subtype of LNECs.