The Sea Lamprey as an Etiological Model for Biliary Atresia
Joint Authors
Chung-Davidson, Yu-Wen
Yeh, Chu-Yin
Li, Weiming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts.
It is the most common cause for pediatric liver transplantation.
In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult with steatohepatitis and fibrosis in the liver.
In this paper, we present new histological evidence and compare the sea lamprey to existing animal models to highlight the advantages and possible limitations of using the sea lamprey to study the etiology and compensatory mechanisms of BA and other liver diseases.
Understanding the signaling factors and genetic networks underlying lamprey BA can provide insights into BA etiology and possible targets to prevent biliary degeneration and to clear fibrosis.
In addition, information from lamprey BA can be used to develop adjunct treatments for patients awaiting or receiving surgical treatments.
Furthermore, the cholestatic adult lamprey has unique adaptive mechanisms that can be used to explore potential treatments for cholestasis and nonalcoholic steatohepatitis (NASH).
American Psychological Association (APA)
Chung-Davidson, Yu-Wen& Yeh, Chu-Yin& Li, Weiming. 2015. The Sea Lamprey as an Etiological Model for Biliary Atresia. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056923
Modern Language Association (MLA)
Chung-Davidson, Yu-Wen…[et al.]. The Sea Lamprey as an Etiological Model for Biliary Atresia. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056923
American Medical Association (AMA)
Chung-Davidson, Yu-Wen& Yeh, Chu-Yin& Li, Weiming. The Sea Lamprey as an Etiological Model for Biliary Atresia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056923