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Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer
Joint Authors
Yemoa, Achille
Gbenou, Joachim
Affolabi, Dissou
Moudachirou, Mansourou
Bigot, André
Anagonou, Séverin
Martin, Anandi
Quetin-Leclercq, Joëlle
Portaels, Françoise
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Buruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing the disease and treating patients.
Research is needed to find cost-effective therapies for this costly disease.
Plants have always been an important source of new pharmacologically active molecules.
Consequently we decided to undertake the study of plants used in traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition.
Extracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin and were assayed for antimycobacterial activities.
Crude hydroethanolic extract from aerial parts of Holarrhena floribunda (G.
Don) T.
Durand and Schinz was found to have significant antimycobacterial activity against M.
ulcerans (MIC = 125 µg/mL).
We describe here the identification of four steroidal alkaloids from Mycobacterium ulcerans growth-inhibiting fractions of the alkaloidal extract of the aerial parts of Holarrhena floribunda.
Holadysamine was purified in sufficient amount to allow the determination of its MCI (=50 µg/mL).
These results give some support to the use of this plant in traditional medicine.
American Psychological Association (APA)
Yemoa, Achille& Gbenou, Joachim& Affolabi, Dissou& Moudachirou, Mansourou& Bigot, André& Anagonou, Séverin…[et al.]. 2015. Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056933
Modern Language Association (MLA)
Yemoa, Achille…[et al.]. Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1056933
American Medical Association (AMA)
Yemoa, Achille& Gbenou, Joachim& Affolabi, Dissou& Moudachirou, Mansourou& Bigot, André& Anagonou, Séverin…[et al.]. Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation and In Vitro Activity of Alkaloids Isolated from Holarrhena floribunda Used in Traditional Treatment of Buruli Ulcer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1056933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056933