Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives
Joint Authors
Mazzesi, Giuseppe
Pisano, Calogera
Lio, Domenico
Ruvolo, Giovanni
Buffa, Silvio
Balistreri, Carmela Rita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Advanced knowledge in the field of stem cell biology and their ability to provide a cue for counteracting several diseases are leading numerous researchers to focus their attention on “regenerative medicine” as possible solutions for cardiovascular diseases (CVDs).
However, the lack of consistent evidence in this arena has hampered the clinical application.
The same condition affects the research on endothelial progenitor cells (EPCs), creating more confusion than comprehension.
In this review, this aspect is discussed with particular emphasis.
In particular, we describe biology and physiology of EPCs, outline their clinical relevance as both new predictive, diagnostic, and prognostic CVD biomarkers and therapeutic agents, discuss advantages, disadvantages, and conflicting data about their use as possible solutions for vascular impairment and clinical applications, and finally underline a very crucial aspect of EPCs “characterization and definition,” which seems to be the real cause of large heterogeneity existing in literature data on this topic.
American Psychological Association (APA)
Balistreri, Carmela Rita& Buffa, Silvio& Pisano, Calogera& Lio, Domenico& Ruvolo, Giovanni& Mazzesi, Giuseppe. 2015. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056934
Modern Language Association (MLA)
Balistreri, Carmela Rita…[et al.]. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1056934
American Medical Association (AMA)
Balistreri, Carmela Rita& Buffa, Silvio& Pisano, Calogera& Lio, Domenico& Ruvolo, Giovanni& Mazzesi, Giuseppe. Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1056934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056934