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Resistance Determinants and Their Association with Different Transposons in the Antibiotic-Resistant Streptococcus pneumoniae
Joint Authors
Korona-Glowniak, Izabela
Siwiec, Radoslaw
Malm, Anna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Multiple resistance of Streptococcus pneumoniae is generally associated with their unique recombination-mediated genetic plasticity and possessing the mobile genetic elements.
The aim of our study was to detect antibiotic resistance determinants and conjugative transposons in 138 antibiotic-resistant pneumococcal strains isolated from nasopharynx of healthy young children from Lublin, Poland.
These strains resistant to tetracycline and/or to chloramphenicol/erythromycin/clindamycin were tested by PCR using the specific genes as markers.
The presence of Tn916 family transposons, carrying tet(M) and int/xisTn916, was observed in all of the tested strains.
Tn916 was detected in 16 strains resistant only to tetracycline.
Tn6002 and Tn3872-related element were found among 99 erm(B)-carrying strains (83.8% and 3.0%, resp.).
Eight strains harbouring mef(E) and erm(B) genes were detected, suggesting the presence of Tn2010 and Tn2017 transposons.
Among 101 chloramphenicol-resistant strains, two variants of Tn5252-related transposon were distinguished depending on the presence of int/xis5252 genes specific for cat gene-containing Tn5252 (75.2% of strains) or intSp23FST81 gene, specific for cat-containing ICESp23FST81 element (24.8% of strains).
In 6 strains Tn916-like and Tn5252-like elements formed a Tn5253-like structure.
Besides clonal dissemination of resistant strains of pneumococci in the population, horizontal transfer of conjugative transposons is an important factor of the high prevalence of antibiotic resistance.
American Psychological Association (APA)
Korona-Glowniak, Izabela& Siwiec, Radoslaw& Malm, Anna. 2015. Resistance Determinants and Their Association with Different Transposons in the Antibiotic-Resistant Streptococcus pneumoniae. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056935
Modern Language Association (MLA)
Korona-Glowniak, Izabela…[et al.]. Resistance Determinants and Their Association with Different Transposons in the Antibiotic-Resistant Streptococcus pneumoniae. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056935
American Medical Association (AMA)
Korona-Glowniak, Izabela& Siwiec, Radoslaw& Malm, Anna. Resistance Determinants and Their Association with Different Transposons in the Antibiotic-Resistant Streptococcus pneumoniae. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056935