Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine DihydrochloridePoly(lactic-co-glycolic acid)
Joint Authors
Xu, Zhiqiang
Lai, Yingzhen
Wu, Dong
Huang, Wenxiu
Huang, Sijia
Chen, Jiang
Zhou, Lin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Titanium (Ti) implants with long-term antibacterial ability and good biocompatibility are highly desirable materials that can be used to prevent implant-associated infections.
In this study, titania nanotubes (TNTs) were synthesized on Ti surfaces through electrochemical anodization.
Octenidine dihydrochloride (OCT)/poly(lactic-co-glycolic acid) (PLGA) was infiltrated into TNTs using a simple solvent-casting technique.
OCT/PLGA-TNTs demonstrated sustained drug release and maintained the characteristic hollow structures of TNTs.
TNTs (200 nm in diameter) alone exhibited slight antibacterial effect and good osteogenic activity but also evidently impaired adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs).
OCT/PLGA-TNTs (100 nm in diameter) supported BMSC adhesion and proliferation and showed good osteogenesis-inducing ability.
OCT/PLGA-TNTs also exhibited good long-term antibacterial ability within the observation period of 7 d.
The synthesized drug carrier with relatively long-term antibacterial ability and enhanced excellent biocompatibility demonstrated significant potential in bone implant applications.
American Psychological Association (APA)
Xu, Zhiqiang& Lai, Yingzhen& Wu, Dong& Huang, Wenxiu& Huang, Sijia& Zhou, Lin…[et al.]. 2015. Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine DihydrochloridePoly(lactic-co-glycolic acid). BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056937
Modern Language Association (MLA)
Xu, Zhiqiang…[et al.]. Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine DihydrochloridePoly(lactic-co-glycolic acid). BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1056937
American Medical Association (AMA)
Xu, Zhiqiang& Lai, Yingzhen& Wu, Dong& Huang, Wenxiu& Huang, Sijia& Zhou, Lin…[et al.]. Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine DihydrochloridePoly(lactic-co-glycolic acid). BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1056937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056937