Association of Tag SNPs and Rare CNVs of the MIR155HGmiR-155 Gene with Epilepsy in the Chinese Han Population
Joint Authors
Ma, Guoda
Fu, Jiawu
Tao, Hua
Cui, Lili
Li, Keshen
Cai, Yujie
Li, You
Zhao, Bin
Zhou, Xu
Yao, Lifen
Li, Wen
Zhou, Haihong
Zhong, Wangtao
Zhang, Shuyan
Xu, Zhien
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
miR-155 likely acts as an important modulator in the inflammatory mechanism of epilepsy, and this study investigated its association with epilepsy from the perspective of molecular genetics.
Methods.
This study enrolled 249 epileptic patients and 289 healthy individuals of the Chinese Han population; 4 tag single-nucleotide polymorphisms (SNPs: rs969885, rs12483428, rs987195, and rs4817027) of the MIR155HG/miR-155 gene were selected, and their association with epilepsy was investigated.
Additionally, this study determined the copy numbers of the MIR155HG/miR-155 gene.
Results.
The TCA haplotype (rs12483428-rs987195-rs4817027) and the AA genotype at rs4817027 conferred higher vulnerability to epilepsy in males.
Stratification by age of onset revealed that the CC haplotype (rs969885-rs987195) was a genetic susceptibility factor for early-onset epilepsy.
Further stratification by drug-resistant status indicated the CC haplotype (rs969885-rs987195) and the AA genotype at rs4817027 were genetic susceptibility factors for drug-resistant epilepsy (DRE) but the CG haplotype (rs987195-rs969885) was a genetically protective factor against DRE.
Besides, 3 epileptic patients with copy number variants of the MIR155HG/miR-155 gene were observed.
Conclusions.
This study first demonstrates the association of MIR155HG/miR-155 tag SNPs with epilepsy and shows that rare CNVs were found exclusively in epileptic patients, clarifying the genetic role of miR-155 in epilepsy.
American Psychological Association (APA)
Tao, Hua& Cui, Lili& Li, You& Zhou, Xu& Ma, Guoda& Yao, Lifen…[et al.]. 2015. Association of Tag SNPs and Rare CNVs of the MIR155HGmiR-155 Gene with Epilepsy in the Chinese Han Population. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056939
Modern Language Association (MLA)
Tao, Hua…[et al.]. Association of Tag SNPs and Rare CNVs of the MIR155HGmiR-155 Gene with Epilepsy in the Chinese Han Population. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056939
American Medical Association (AMA)
Tao, Hua& Cui, Lili& Li, You& Zhou, Xu& Ma, Guoda& Yao, Lifen…[et al.]. Association of Tag SNPs and Rare CNVs of the MIR155HGmiR-155 Gene with Epilepsy in the Chinese Han Population. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056939