Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
Joint Authors
Xu, Xin-Jian
Shao, Fang-Yang
He, Yuan
Zhu, Guanghui
Chen, Beimin
Zhou, Min
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In clinic, oral leukoplakia (OLK) may develop into oral cancer.
However, the mechanism underlying this transformation is still unclear.
In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles.
In particular, we find some network modules as well as their miRNA regulators that play important roles in the development of OLK to oral cancer.
Among these network modules, 91.67% of genes and 37.5% of miRNAs have been previously reported to be related to oral cancer in literature.
The promising results demonstrate the effectiveness and efficiency of our proposed approach.
American Psychological Association (APA)
Zhu, Guanghui& He, Yuan& Shao, Fang-Yang& Chen, Beimin& Zhou, Min& Xu, Xin-Jian. 2015. Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056958
Modern Language Association (MLA)
Zhu, Guanghui…[et al.]. Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056958
American Medical Association (AMA)
Zhu, Guanghui& He, Yuan& Shao, Fang-Yang& Chen, Beimin& Zhou, Min& Xu, Xin-Jian. Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056958