Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits
Joint Authors
Fan, Jianglin
Liu, Enqi
Zhao, Sihai
Li, Yafeng
Gao, Shoucui
Wang, Xiaojing
Sun, Lijing
Cheng, Daxing
Bai, Liang
Guan, Hua
Wang, Rong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Circulating urotensin II (UII) is involved in the development of atherosclerosis.
However, the role of autocrine UII in the development of atherosclerosis remains unclear.
Here, we tested the hypothesis that autocrine UII would promote atherosclerosis.
Transgenic rabbits were created as a model to study macrophage-specific expressing human UII (hUII) and used to investigate the role of autocrine UII in the development of atherosclerosis.
Transgenic rabbits and their nontransgenic littermates were fed a high cholesterol diet to induce atherosclerosis.
Comparing the transgenic rabbits with their nontransgenic littermates, it was observed that hUII expression increased the macrophage-positive area in the atherosclerotic lesions by 45% and the positive area ratio by 56% in the transgenic rabbits.
Autocrine hUII significantly decreased the smooth muscle cell-positive area ratio in transgenic rabbits (by 54%), without affecting the plasma levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose and adipose tissue contents.
These results elucidated for the first time that autocrine UII plays an important role in the development of atherosclerosis by increasing the accumulation of macrophage-derived foam cell.
American Psychological Association (APA)
Zhao, Sihai& Li, Yafeng& Gao, Shoucui& Wang, Xiaojing& Sun, Lijing& Cheng, Daxing…[et al.]. 2015. Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056967
Modern Language Association (MLA)
Zhao, Sihai…[et al.]. Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056967
American Medical Association (AMA)
Zhao, Sihai& Li, Yafeng& Gao, Shoucui& Wang, Xiaojing& Sun, Lijing& Cheng, Daxing…[et al.]. Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056967