MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes
Joint Authors
Matragoon, Suraporn
Fulzele, Sadanand
El-Sherbini, Ahmed
Ahmad, Saif
Sangani, Rajnikumar
Radhakrishnan, Reshmitha
Liou, Gregory I.
El-Remessy, Azza B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyperglycemia- (HG-) Amadori-glycated albumin- (AGA-) induced activation of microglia and monocytes and their adherence to retinal vascular endothelial cells contribute to retinal inflammation leading to diabetic retinopathy (DR).
There is a great need for early detection of DR before demonstrable tissue damages become irreversible.
Extracellular adenosine, required for endogenous anti-inflammation, is regulated by the interplay of equilibrative nucleoside transporter with adenosine deaminase (ADA) and adenosine kinase.
ADA, including ADA1 and ADA2, exists in all organisms.
However, because ADA2 gene has not been identified in mouse genome, how diabetes alters adenosine-dependent anti-inflammation remains unclear.
Studies of pig retinal microglia and human macrophages revealed a causal role of ADA2 in inflammation.
Database search suggested miR-146b-3p recognition sites in the 3′-UTR of ADA2 mRNA.
Coexpression of miR-146b-3p, but not miR-146-5p or nontargeting miRNA, with 3′-UTR of the ADA2 gene was necessary to suppress a linked reporter gene.
In the vitreous of diabetic patients, decreased miR-146b-3p is associated with increased ADA2 activity.
Ectopic expression of miR-146b-3p suppressed ADA2 expression, activity, and TNF-α release in the AGA-treated human macrophages.
These results suggest a regulatory role of miR-146b-3p in diabetes related retinal inflammation by suppressing ADA2.
American Psychological Association (APA)
Fulzele, Sadanand& El-Sherbini, Ahmed& Ahmad, Saif& Sangani, Rajnikumar& Matragoon, Suraporn& El-Remessy, Azza B.…[et al.]. 2015. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056977
Modern Language Association (MLA)
Fulzele, Sadanand…[et al.]. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056977
American Medical Association (AMA)
Fulzele, Sadanand& El-Sherbini, Ahmed& Ahmad, Saif& Sangani, Rajnikumar& Matragoon, Suraporn& El-Remessy, Azza B.…[et al.]. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056977