MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes

Joint Authors

Matragoon, Suraporn
Fulzele, Sadanand
El-Sherbini, Ahmed
Ahmad, Saif
Sangani, Rajnikumar
Radhakrishnan, Reshmitha
Liou, Gregory I.
El-Remessy, Azza B.

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-03-01

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Hyperglycemia- (HG-) Amadori-glycated albumin- (AGA-) induced activation of microglia and monocytes and their adherence to retinal vascular endothelial cells contribute to retinal inflammation leading to diabetic retinopathy (DR).

There is a great need for early detection of DR before demonstrable tissue damages become irreversible.

Extracellular adenosine, required for endogenous anti-inflammation, is regulated by the interplay of equilibrative nucleoside transporter with adenosine deaminase (ADA) and adenosine kinase.

ADA, including ADA1 and ADA2, exists in all organisms.

However, because ADA2 gene has not been identified in mouse genome, how diabetes alters adenosine-dependent anti-inflammation remains unclear.

Studies of pig retinal microglia and human macrophages revealed a causal role of ADA2 in inflammation.

Database search suggested miR-146b-3p recognition sites in the 3′-UTR of ADA2 mRNA.

Coexpression of miR-146b-3p, but not miR-146-5p or nontargeting miRNA, with 3′-UTR of the ADA2 gene was necessary to suppress a linked reporter gene.

In the vitreous of diabetic patients, decreased miR-146b-3p is associated with increased ADA2 activity.

Ectopic expression of miR-146b-3p suppressed ADA2 expression, activity, and TNF-α release in the AGA-treated human macrophages.

These results suggest a regulatory role of miR-146b-3p in diabetes related retinal inflammation by suppressing ADA2.

American Psychological Association (APA)

Fulzele, Sadanand& El-Sherbini, Ahmed& Ahmad, Saif& Sangani, Rajnikumar& Matragoon, Suraporn& El-Remessy, Azza B.…[et al.]. 2015. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056977

Modern Language Association (MLA)

Fulzele, Sadanand…[et al.]. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1056977

American Medical Association (AMA)

Fulzele, Sadanand& El-Sherbini, Ahmed& Ahmad, Saif& Sangani, Rajnikumar& Matragoon, Suraporn& El-Remessy, Azza B.…[et al.]. MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1056977

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1056977