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Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock
Joint Authors
Molnar, Zsolt
Boros, Mihaly
Németh, Márton
Palágyi, Péter
Rostás, Andrea
Kaszaki, Jozsef
Erces, Daniel
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion.
We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage.
Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n=9) and shock groups (n=27).
Hemorrhagic shock was induced by reducing mean arterial pressure (MAP) to 40 mmHg for 60 min, after which fluid resuscitation started aiming to increase MAP to 75% of the baseline value (60–180 min).
Sublingual carbon-dioxide partial pressure was measured by tonometry, using a specially coiled silicone rubber tube.
Mucosal red blood cell velocity (RBCV) and capillary perfusion rate (CPR) were assessed by orthogonal polarization spectral (OPS) imaging.
In the 60 min shock phase a significant drop in cardiac index was accompanied by reduction in sublingual RBCV and CPR and significant increase in the sublingual mucosal-to-arterial PCO2 gap (PSLCO2 gap), which significantly improved during the 120 min resuscitation phase.
There was significant correlation between PSLCO2 gap and sublingual RBCV (r=-0.65, p<0.0001), CPR (r=-0.64, p<0.0001), central venous oxygen saturation (r=-0.50, p<0.0001), and central venous-to-arterial PCO2 difference (r=0.62, p<0.0001).
This new sublingual tonometer may be an appropriate tool for the indirect evaluation of circulatory changes in shock.
American Psychological Association (APA)
Palágyi, Péter& Kaszaki, Jozsef& Rostás, Andrea& Erces, Daniel& Németh, Márton& Boros, Mihaly…[et al.]. 2015. Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056978
Modern Language Association (MLA)
Palágyi, Péter…[et al.]. Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056978
American Medical Association (AMA)
Palágyi, Péter& Kaszaki, Jozsef& Rostás, Andrea& Erces, Daniel& Németh, Márton& Boros, Mihaly…[et al.]. Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056978