![](/images/graphics-bg.png)
Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa
Joint Authors
Peraza-Sánchez, Sergio R.
Slusarz, Anna
Jackson, Glenn
Drenkhahn, Sara K.
Lubahn, Dennis B.
Caamal-Fuentes, Edgar
Moo-Puc, Rosa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study was to investigate antiproliferative activity of bonediol, an alkyl catechol isolated from the Mayan medicinal plant Bonellia macrocarpa.
Bonediol was assessed for growth inhibition of androgen-sensitive (LNCaP), androgen-insensitive (PC-3), and metastatic androgen-insensitive (PC-3M) human prostate tumor cells; toxicity on normal cell line (HEK 293) was also evaluated.
Hedgehog pathway was evaluated and competitive 3H-estradiol ligand binding assay was performed.
Additionally, antioxidant activity on Nrf2-ARE pathway was evaluated.
Bonediol induced a growth inhibition on prostate cancer cell lines (IC50 from 8.5 to 20.6 µM).
Interestingly, bonediol binds to both estrogen receptors (ERα (2.5 µM) and ERβ (2.1 µM)) and displaces the native ligand E2 (17β-estradiol).
No significant activity was found in the Hedgehog pathway.
Additionally, activity of bonediol on Nrf2-ARE pathway suggested that bonediol could induce oxidative stress and activation of detoxification enzymes at 1 µM (3.8-fold).
We propose that the compound bonediol may serve as a potential chemopreventive treatment with therapeutic potential against prostate cancer.
American Psychological Association (APA)
Moo-Puc, Rosa& Caamal-Fuentes, Edgar& Peraza-Sánchez, Sergio R.& Slusarz, Anna& Jackson, Glenn& Drenkhahn, Sara K.…[et al.]. 2015. Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056980
Modern Language Association (MLA)
Moo-Puc, Rosa…[et al.]. Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1056980
American Medical Association (AMA)
Moo-Puc, Rosa& Caamal-Fuentes, Edgar& Peraza-Sánchez, Sergio R.& Slusarz, Anna& Jackson, Glenn& Drenkhahn, Sara K.…[et al.]. Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1056980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056980