Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway
Joint Authors
Seo, Eun-Min
Sharma, Ashish Ranjan
Nam, Ju-Suk
Sharma, Garima
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism.
The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors.
Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes Wnt signaling pathway.
The other class consists of Dickkopf (DKK) proteins family that binds to Wnt receptor complex.
The present review discusses the disease related association of various polymorphisms in Wnt signaling modulators.
Furthermore, this review also highlights that some of the sFRPs and DKKs are unable to act as an antagonist for Wnt signaling pathway and thus their function needs to be explored more extensively.
American Psychological Association (APA)
Sharma, Garima& Sharma, Ashish Ranjan& Seo, Eun-Min& Nam, Ju-Suk. 2015. Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056982
Modern Language Association (MLA)
Sharma, Garima…[et al.]. Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056982
American Medical Association (AMA)
Sharma, Garima& Sharma, Ashish Ranjan& Seo, Eun-Min& Nam, Ju-Suk. Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056982