Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance
Joint Authors
Singh, Ajay
Srivastava, Sanjeev K.
Arora, Sumit
Averett, Courey
Singh, Seema
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that regulate a variety of biological processes such as differentiation, development, and survival.
Recent studies suggest that miRNAs are dysregulated in cancer and play critical roles in cancer initiation, progression, and chemoresistance.
Therefore, exploitation of miRNAs as targets for cancer prevention and therapy could be a promising approach.
Extensive evidence suggests that many naturally occurring phytochemicals regulate the expression of numerous miRNAs involved in the pathobiology of cancer.
Therefore, an understanding of the regulation of miRNAs by phytochemicals in cancer, their underlying molecular mechanisms, and functional consequences on tumor pathophysiology may be useful in formulating novel strategies to combat this devastating disease.
These aspects are discussed in this review paper with an objective of highlighting the significance of these observations from the translational standpoint.
American Psychological Association (APA)
Srivastava, Sanjeev K.& Arora, Sumit& Averett, Courey& Singh, Seema& Singh, Ajay. 2015. Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056986
Modern Language Association (MLA)
Srivastava, Sanjeev K.…[et al.]. Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1056986
American Medical Association (AMA)
Srivastava, Sanjeev K.& Arora, Sumit& Averett, Courey& Singh, Seema& Singh, Ajay. Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1056986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056986