Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy
Joint Authors
Niezgoda, Anna
Niezgoda, Piotr
Czajkowski, Rafał
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The incidence of malignant melanoma is increasing.
The majority of patients are diagnosed in early stages when the disease is highly curable.
However, the more advanced or metastatic cases have always been a challenge for clinicians.
The poor prognosis for patients with melanoma is now changing as numerous of promising approaches have appeared recently.
The discovery of aberrations of pathways responsible for intracellular signal transduction allowed us to introduce agents specifically targeting the mutated cascades.
Numerous clinical studies have been conducted to improve effectiveness of melanoma treatment.
From 2011 until now, the U.S.
FDA has approved seven novel agents, such as BRAF-inhibitors (vemurafenib 2011, dabrafenib 2013), MEK-inhibitors (trametinib 2013), anti-PD1 antibodies (nivolumab 2014, pembrolizumab 2014), anti-CTLA-4 antibody (ipilimumab 2011), or peginterferon-alfa-2b (2011) intended to be used in most advanced cases of melanoma.
Nevertheless, clinicians continue working on new possible methods of treatment as resistance to the novel drugs is a commonly observed problem.
This paper is based on latest data published until the end of January 2015.
American Psychological Association (APA)
Niezgoda, Anna& Niezgoda, Piotr& Czajkowski, Rafał. 2015. Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056998
Modern Language Association (MLA)
Niezgoda, Anna…[et al.]. Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy. BioMed Research International No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1056998
American Medical Association (AMA)
Niezgoda, Anna& Niezgoda, Piotr& Czajkowski, Rafał. Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1056998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056998