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Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells
Joint Authors
Xu, Yan-mei
Liao, Xing-yun
Chen, Xie-wan
Li, De-zhi
Sun, Jian-guo
Liao, Rong-xia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Radiotherapy (RT) is a key therapeutic strategy for lung cancer, the most common cause of cancer-related deaths worldwide, but radioresistance often occurs and leads to failure of RT.
It is therefore important to clarify the mechanism underlying radioresistance in lung cancer.
Cancer stem cells (CSCs) are considered the fundamental reason for radioresistance.
MicroRNAs (miRNAs) have been regarded as important regulatory molecules of CSCs, carcinogenesis, and treatment response of cancers.
It is crucial to clarify how regulation of miRNAs affects repair of DNA damage, redistribution, repopulation, reoxygenation, and radiosensitivity (5R) of lung cancer stem cells (LCSCs).
A thorough understanding of the regulation of miRNAs affecting 5R of LCSCs has potential impact on identifying novel targets and thus may improve the efficacy of lung cancer radiotherapy.
American Psychological Association (APA)
Xu, Yan-mei& Liao, Xing-yun& Chen, Xie-wan& Li, De-zhi& Sun, Jian-guo& Liao, Rong-xia. 2015. Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057000
Modern Language Association (MLA)
Xu, Yan-mei…[et al.]. Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057000
American Medical Association (AMA)
Xu, Yan-mei& Liao, Xing-yun& Chen, Xie-wan& Li, De-zhi& Sun, Jian-guo& Liao, Rong-xia. Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057000