![](/images/graphics-bg.png)
Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors
Joint Authors
Zmorzyński, Szymon
Świderska-Kołacz, Grażyna
Koczkodaj, Dorota
Filip, Agata Anna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Antioxidant compounds such as glutathione and its enzymes have become the focus of attention of medical sciences.
Glutathione, a specific tripeptide, is involved in many intercellular processes.
The glutathione concentration is determined by the number of GAG repeats in gamma-glutamylcysteine synthetase.
GAG polymorphisms are associated with an increased risk of schizophrenia, berylliosis, diabetes, lung cancer, and nasopharyngeal tumors.
Cancer cells with high glutathione concentration are resistant to chemotherapy treatment.
The oxidized form of glutathione is formed by glutathione peroxidases (GPXs).
The changes in activity of GPX1, GPX2, and GPX3 isoforms may be associated with the development of cancers, for example, prostate cancer or even colon cancer.
Detoxification of glutathione conjugates is possible due to activity of glutathione S-transferases (GSTs).
Polymorphisms in GSTM1, GSTP1, and GSTO1 enzymes increase the risk of developing breast cancer and hepatocellular carcinoma.
Gamma-glutamyl transpeptidases (GGTs) are responsible for glutathione degradation.
Increased activity of GGT correlates with adverse prognosis in patients with breast cancer.
Studies on genes encoding glutathione enzymes are continued in order to determine the correlation between DNA polymorphisms in cancer patients.
American Psychological Association (APA)
Zmorzyński, Szymon& Świderska-Kołacz, Grażyna& Koczkodaj, Dorota& Filip, Agata Anna. 2015. Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057010
Modern Language Association (MLA)
Zmorzyński, Szymon…[et al.]. Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1057010
American Medical Association (AMA)
Zmorzyński, Szymon& Świderska-Kołacz, Grażyna& Koczkodaj, Dorota& Filip, Agata Anna. Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1057010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057010