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Delivery of Antibiotics from Cementless Titanium-Alloy Cubes May Be a Novel Way to Control Postoperative Infections
Joint Authors
Dicks, L. M. T.
Dimitrov, Dimitar M.
Oosthuizen, Gert A.
Bezuidenhout, Martin B.
van Staden, Anton D.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bacterial colonisation and biofilm formation onto orthopaedic devices are difficult to eradicate.
In most cases infection is treated by surgical removal of the implant and cleaning of the infected area, followed by extensive treatment with broad-spectrum antibiotics.
Such treatment causes great discomfort, is expensive, and is not always successful.
In this study we report on the release of vancomycin through polyethersulfone membranes from channels in cementless titanium-alloy cubes.
The cubes were constructed with LaserCUSING from Ti6Al4V ELI powder.
Vancomycin was released by non-Fickian anomalous (constraint) diffusion.
Approximately 50% of the vancomycin was released within the first 17 h.
However, sustained delivery of vancomycin for 100 h was possible by reinjecting the channels.
Refillable implants may be a novel way to control postoperative infections.
American Psychological Association (APA)
Bezuidenhout, Martin B.& van Staden, Anton D.& Oosthuizen, Gert A.& Dimitrov, Dimitar M.& Dicks, L. M. T.. 2015. Delivery of Antibiotics from Cementless Titanium-Alloy Cubes May Be a Novel Way to Control Postoperative Infections. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057024
Modern Language Association (MLA)
Bezuidenhout, Martin B.…[et al.]. Delivery of Antibiotics from Cementless Titanium-Alloy Cubes May Be a Novel Way to Control Postoperative Infections. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057024
American Medical Association (AMA)
Bezuidenhout, Martin B.& van Staden, Anton D.& Oosthuizen, Gert A.& Dimitrov, Dimitar M.& Dicks, L. M. T.. Delivery of Antibiotics from Cementless Titanium-Alloy Cubes May Be a Novel Way to Control Postoperative Infections. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057024