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Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients
Joint Authors
Beomonte Zobel, Bruno
Di Giampietro, Ilenia
Liguori, Carlo
Pitocco, Francesca
De Vivo, Aldo Eros
Schena, Emiliano
Giurazza, Francesco
Sorrentino, Francesco
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR).
We supposed that TI group could be differentiated from the TM group based on T 2 ∗ and that the TI group could demonstrate higher cardiac output.
Methods.
A retrospective analysis of 242 patients with TM and TI was performed (132 males, 110 females; mean age 39.6 ± 8 years; 186 TM, 56 TI).
Iron load was assessed by T 2 ∗ measurements; volumetric functions were analyzed using steady-state-free precession sequences.
Results.
Significant difference in left-right heart performance was observed between TM with iron overload and TI patients and between TM with iron overload and TM without iron overload ( P < 0.05 ); no significant differences were observed between TM without iron overload and TI patients.
A significant correlation was observed between T 2 ∗ and ejection fraction of right ventricle- (RV-) ejection fraction of left ventricle (LV); an inverse correlation was present among T 2 ∗ values and end-diastolic volume of LV, end-systolic volume of LV, stroke volume of LV, end-diastolic volume of RV, end-systolic volume of RV, and stroke volume of RV.
Conclusions.
CMR is a leading approach for cardiac risk evaluation of TM and TI patients.
American Psychological Association (APA)
Liguori, Carlo& Pitocco, Francesca& Di Giampietro, Ilenia& De Vivo, Aldo Eros& Schena, Emiliano& Giurazza, Francesco…[et al.]. 2015. Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057030
Modern Language Association (MLA)
Liguori, Carlo…[et al.]. Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057030
American Medical Association (AMA)
Liguori, Carlo& Pitocco, Francesca& Di Giampietro, Ilenia& De Vivo, Aldo Eros& Schena, Emiliano& Giurazza, Francesco…[et al.]. Magnetic Resonance Comparison of Left-Right Heart Volumetric and Functional Parameters in Thalassemia Major and Thalassemia Intermedia Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057030