Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering
Joint Authors
Du, Dajiang
Asaoka, Teruo
Shinohara, Makoto
Kageyama, Tomonori
Ushida, Takashi
Furukawa, Katsuko Sakai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Porous ceramic scaffolds with shapes matching the bone defects may result in more efficient grafting and healing than the ones with simple geometries.
Using computer-assisted microstereolithography (MSTL), we have developed a novel gelcasting indirect MSTL technology and successfully fabricated two scaffolds according to CT images of rabbit femur.
Negative resin molds with outer 3D dimensions conforming to the femur and an internal structure consisting of stacked meshes with uniform interconnecting struts, 0.5 mm in diameter, were fabricated by MSTL.
The second mold type was designed for cortical bone formation.
A ceramic slurry of beta-tricalcium phosphate ( β -TCP) with room temperature vulcanization (RTV) silicone as binder was cast into the molds.
After the RTV silicone was completely cured, the composite was sintered at 1500°C for 5 h.
Both gross anatomical shape and the interpenetrating internal network were preserved after sintering.
Even cortical structure could be introduced into the customized scaffolds, which resulted in enhanced strength.
Biocompatibility was confirmed by vital staining of rabbit bone marrow mesenchymal stromal cells cultured on the customized scaffolds for 5 days.
This fabrication method could be useful for constructing bone substitutes specifically designed according to local anatomical defects.
American Psychological Association (APA)
Du, Dajiang& Asaoka, Teruo& Shinohara, Makoto& Kageyama, Tomonori& Ushida, Takashi& Furukawa, Katsuko Sakai. 2015. Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057039
Modern Language Association (MLA)
Du, Dajiang…[et al.]. Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057039
American Medical Association (AMA)
Du, Dajiang& Asaoka, Teruo& Shinohara, Makoto& Kageyama, Tomonori& Ushida, Takashi& Furukawa, Katsuko Sakai. Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057039