Role of NEK2A in Human Cancer and Its Therapeutic Potentials
Joint Authors
Zhan, Fenghuang
Gu, Zhimin
Xia, Jiliang
Franqui Machin, Reinaldo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chromosome instability (CIN) has been identified as a common feature of most human cancers.
A number of centrosomal kinases are thought to cause CIN in cancer cells.
Part of those centrosomal kinases exhibit elevated expression in a wide variety of tumours and cancer cell lines.
Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase.
Recent studies from our group and others revealed that a centrosomal kinase, Never in Mitosis (NIMA) Related Kinase 2A (NEK2A), is frequently upregulated in multiple types of human cancers.
Uncontrolled activity of NEK2A activates several oncogenic pathways and ABC transporters, thereby leading to CIN, cancer cell proliferation, metastasis, and enhanced drug resistance.
In this paper, we highlight recent findings on the aberrant expression and functional significance of NEK2A in human cancers and emphasize their significance for therapeutic potentials.
American Psychological Association (APA)
Xia, Jiliang& Franqui Machin, Reinaldo& Gu, Zhimin& Zhan, Fenghuang. 2015. Role of NEK2A in Human Cancer and Its Therapeutic Potentials. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057053
Modern Language Association (MLA)
Xia, Jiliang…[et al.]. Role of NEK2A in Human Cancer and Its Therapeutic Potentials. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057053
American Medical Association (AMA)
Xia, Jiliang& Franqui Machin, Reinaldo& Gu, Zhimin& Zhan, Fenghuang. Role of NEK2A in Human Cancer and Its Therapeutic Potentials. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057053