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Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
Joint Authors
Zhou, Tingyang
Chuang, Chia-Chen
Zuo, Li
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions.
The occlusion of blood flow to the tissue, termed ischemia, can be especially detrimental to the heart due to its high energy demand.
Several cellular alterations have been observed upon the onset of ischemia.
The danger created by cardiac ischemia is somewhat paradoxical in that a return of blood to the tissue can result in further damage.
Reactive oxygen species (ROS) have been studied intensively to reveal their role in myocardial I/R injury.
Under normal conditions, ROS function as a mediator in many cell signaling pathways.
However, stressful environments significantly induce the generation of ROS which causes the level to exceed body’s antioxidant defense system.
Such altered redox homeostasis is implicated in myocardial I/R injury.
Despite the detrimental effects from ROS, low levels of ROS have been shown to exert a protective effect in the ischemic preconditioning.
In this review, we will summarize the detrimental role of ROS in myocardial I/R injury, the protective mechanism induced by ROS, and potential treatments for ROS-related myocardial injury.
American Psychological Association (APA)
Zhou, Tingyang& Chuang, Chia-Chen& Zuo, Li. 2015. Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057064
Modern Language Association (MLA)
Zhou, Tingyang…[et al.]. Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1057064
American Medical Association (AMA)
Zhou, Tingyang& Chuang, Chia-Chen& Zuo, Li. Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1057064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057064