Enhanced Vascularization in Hybrid PCLGelatin Fibrous Scaffolds with Sustained Release of VEGF
Joint Authors
Kong, Deling
Wang, Kai
Chen, Xuejiao
Pan, Yiwa
Cui, Yun
Zhou, Xin
Zhao, Qiang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Creating a long-lasting and functional vasculature represents one of the most fundamental challenges in tissue engineering.
VEGF has been widely accepted as a potent angiogenic factor involved in the early stages of blood vessel formation.
In this study, fibrous scaffolds that consist of PCL and gelatin fibers were fabricated.
The gelatin fibers were further functionalized by heparin immobilization, which provides binding sites for VEGF and thus enables the sustained release of VEGF.
In vitro release test confirms the sustained releasing profile of VEGF, and stable release was observed over a time period of 25 days.
In vitro cell assay indicates that VEGF release significantly promoted the proliferation of endothelial cells.
More importantly, in vivo subcutaneous implantation reflects that vascularization has been effectively enhanced in the PCL/gelatin scaffolds compared with the PCL counterpart due to the sustained release of VEGF.
Therefore, the heparinized PCL/gelatin scaffolds developed in this study may be a promising candidate for regeneration of complex tissues with sufficient vascularization.
American Psychological Association (APA)
Wang, Kai& Chen, Xuejiao& Pan, Yiwa& Cui, Yun& Zhou, Xin& Kong, Deling…[et al.]. 2015. Enhanced Vascularization in Hybrid PCLGelatin Fibrous Scaffolds with Sustained Release of VEGF. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057065
Modern Language Association (MLA)
Wang, Kai…[et al.]. Enhanced Vascularization in Hybrid PCLGelatin Fibrous Scaffolds with Sustained Release of VEGF. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057065
American Medical Association (AMA)
Wang, Kai& Chen, Xuejiao& Pan, Yiwa& Cui, Yun& Zhou, Xin& Kong, Deling…[et al.]. Enhanced Vascularization in Hybrid PCLGelatin Fibrous Scaffolds with Sustained Release of VEGF. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057065