Rebamipide Improves Chronic Inflammation in the Lesser Curvature of the Corpus after Helicobacter pylori Eradication: A Multicenter Study
Joint Authors
Tanaka, Shinji
Haruma, K.
Kamada, Tomoari
Sato, Motonori
Tokutomi, Tadashi
Watanabe, Tetsuo
Murao, Takahisa
Matsumoto, Hiroshi
Manabe, Noriaki
Inoue, Kazuhiko
Shiotani, Akiko
Akiyama, Takashi
Hata, Jiro
Ito, Masanori
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aim.
Although many epidemiologic studies have shown that Helicobacter pylori eradication has prophylactic effects on gastric cancer, it does not completely eliminate the risk of gastric cancer.
We aimed to investigate the changes in histological gastritis in patients receiving rebamipide treatment after H.
pylori eradication.
Methods.
206 patients who had undergone H.
pylori eradication were evaluated.
Of these, 169 patients who achieved successful eradication were randomly allocated to 2 groups: the rebamipide group (n = 82) and the untreated group (n = 87).
The primary endpoints were histopathological findings according to the updated Sydney system at the start of the study and after 1 year.
Results.
Final assessment for histological gastritis was possible in 50 cases from the rebamipide group and 53 cases from the untreated group.
The activity and atrophy improved in both the rebamipide and untreated groups, and no significant intergroup differences were observed.
Chronic inflammation affecting the lesser curvature of the corpus was significantly improved in the rebamipide group compared to in the untreated group ( 1.12 ± 0.08 versus 1.35 ± 0.08 ; P = 0.043).
Conclusions.
Rebamipide treatment after H.
pylori eradication alleviated chronic inflammation in the lesser curvature of the corpus compared to that in the untreated group.
This trial is registered with UMIN000002369.
American Psychological Association (APA)
Kamada, Tomoari& Sato, Motonori& Tokutomi, Tadashi& Watanabe, Tetsuo& Murao, Takahisa& Matsumoto, Hiroshi…[et al.]. 2015. Rebamipide Improves Chronic Inflammation in the Lesser Curvature of the Corpus after Helicobacter pylori Eradication: A Multicenter Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057067
Modern Language Association (MLA)
Kamada, Tomoari…[et al.]. Rebamipide Improves Chronic Inflammation in the Lesser Curvature of the Corpus after Helicobacter pylori Eradication: A Multicenter Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057067
American Medical Association (AMA)
Kamada, Tomoari& Sato, Motonori& Tokutomi, Tadashi& Watanabe, Tetsuo& Murao, Takahisa& Matsumoto, Hiroshi…[et al.]. Rebamipide Improves Chronic Inflammation in the Lesser Curvature of the Corpus after Helicobacter pylori Eradication: A Multicenter Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057067