Synthesis and Characterization of Biodegradable Polyurethane for Hypopharyngeal Tissue Engineering
Joint Authors
Zhu, Yabin
Lu, Dakai
Li, Qun
Shen, Zhisen
Lu, Dakai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Biodegradable crosslinked polyurethane (cPU) was synthesized using polyethylene glycol (PEG), L-lactide (L-LA), and hexamethylene diisocyanate (HDI), with iron acetylacetonate (Fe(acac)3) as the catalyst and PEG as the extender.
Chemical components of the obtained polymers were characterized by FTIR spectroscopy, 1H NMR spectra, and Gel Permeation Chromatography (GPC).
The thermodynamic properties, mechanical behaviors, surface hydrophilicity, degradability, and cytotoxicity were tested via differential scanning calorimetry (DSC), tensile tests, contact angle measurements, and cell culture.
The results show that the synthesized cPU possessed good flexibility with quite low glass transition temperature (Tg, −22°C) and good wettability.
Water uptake measured as high as 229.7 ± 18.7%.
These properties make cPU a good candidate material for engineering soft tissues such as the hypopharynx.
In vitro and in vivo tests showed that cPU has the ability to support the growth of human hypopharyngeal fibroblasts and angiogenesis was observed around cPU after it was implanted subcutaneously in SD rats.
American Psychological Association (APA)
Shen, Zhisen& Lu, Dakai& Li, Qun& Lu, Dakai& Zhu, Yabin. 2015. Synthesis and Characterization of Biodegradable Polyurethane for Hypopharyngeal Tissue Engineering. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057086
Modern Language Association (MLA)
Shen, Zhisen…[et al.]. Synthesis and Characterization of Biodegradable Polyurethane for Hypopharyngeal Tissue Engineering. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1057086
American Medical Association (AMA)
Shen, Zhisen& Lu, Dakai& Li, Qun& Lu, Dakai& Zhu, Yabin. Synthesis and Characterization of Biodegradable Polyurethane for Hypopharyngeal Tissue Engineering. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1057086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057086