Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications
Joint Authors
Ambrosio, Luigi
Borzacchiello, Assunta
Russo, Luisa
Malle, Birgitte M.
Schwach-Abdellaoui, Khadija
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hyaluronic acid (HA) hydrogels, obtained by cross-linking HA molecules with divinyl sulfone (DVS) based on a simple, reproducible, and safe process that does not employ any organic solvents, were developed.
Owing to an innovative preparation method the resulting homogeneous hydrogels do not contain any detectable residual cross-linking agent and are easier to inject through a fine needle.
HA hydrogels were characterized in terms of degradation and biological properties, viscoelasticity, injectability, and network structural parameters.
They exhibit a rheological behaviour typical of strong gels and show improved viscoelastic properties by increasing HA concentration and decreasing HA/DVS weight ratio.
Furthermore, it was demonstrated that processes such as sterilization and extrusion through clinical needles do not imply significant alteration of viscoelastic properties.
Both SANS and rheological tests indicated that the cross-links appear to compact the network, resulting in a reduction of the mesh size by increasing the cross-linker amount.
In vitro degradation tests of the HA hydrogels demonstrated that these new hydrogels show a good stability against enzymatic degradation, which increases by increasing HA concentration and decreasing HA/DVS weight ratio.
Finally, the hydrogels show a good biocompatibility confirmed by in vitro tests.
American Psychological Association (APA)
Borzacchiello, Assunta& Russo, Luisa& Malle, Birgitte M.& Schwach-Abdellaoui, Khadija& Ambrosio, Luigi. 2015. Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057087
Modern Language Association (MLA)
Borzacchiello, Assunta…[et al.]. Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1057087
American Medical Association (AMA)
Borzacchiello, Assunta& Russo, Luisa& Malle, Birgitte M.& Schwach-Abdellaoui, Khadija& Ambrosio, Luigi. Hyaluronic Acid Based Hydrogels for Regenerative Medicine Applications. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1057087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057087