Lipid peroxidation and paraoxonase activity in severe pre-eclamptic women

Abstract EN

Pre-eclampsia is one of the most serious complications of pregnancy.

Free radicals have been implicated in the pathophysiology of pre-eclampsia.

The aim of this study was to evaluate lipid peroxidation, paraoxonase activity, arylesterase activity and serum lipid profiles in severe pre-eclamptic women.

The study included 40 Patients with severe pre-eclampsia in the third trimester with age range 26-31 years and 20 normotensive pregnant women also in the third trimester as a control group with age range 28-32 years.

Subjects and Methods: All studied individuals were submitted to full history taking, clinical examination, abdominal ultrasound, liver function tests {aspartate transaminase (AST), alanine transaminase (ALT)}, kidney function tests ( urea and creatinine), serum lipid profiles{ Cholesterol (Ch), Triglycerides (TG), Low Density Lipoprotein cholesterol (LDLc), High Density Lipoprotein cholesterol (HDLc)}, Malondialdehyde (MDA) as indicator of lipid peroxidation, paraoxonase (PON) and arylesterase activities.

Results: The study showed a significant increase of AST, ALT, urea, creatinine, Ch, LDLc and MDA in severe pre-eclamptic women when compared with normotensive pregnant women (P< 0.001), TG showed a significant increase in severe pre-eclamptic women when compared with normotensive pregnant women (P<0.05), while PON and arylesterase activities showed a significant decrease in Severe pre-eclamptic women when compared with normotensive pregnant women (P < 0.001), HDLc showed a significant decrease in Severe pre-eclamptic women when compared with normotensive pregnant women (P < 0.05).

A significant negative correlation was found between MDA and PON (r = -0.43, P< 0.05), while a positive correlation was found between HDLc and PON( r = 0.82, P < 0.001) and also a positive correlation was found between HDLc and arylesterase (r = 0.42, P < 0.05).

Conclusion: It could be concluded that excessive lipid peroxidation, decrease paraoxonase and arylesterase activities together with abnormal lipid profiles may have a role in the pathogenesis of pre-eclampsia.