Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer
Joint Authors
Izzo, Francesco
Bimonte, Sabrina
Barbieri, Antonio
Palma, Giuseppe
Arra, Claudio
Luciano, Antonio
Rea, Domenica
D'Aiuto, Massimiliano
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Breast cancer is considered the most common cancer for women worldwide and it is now the second leading cause of cancer-related deaths among females in the world.
Since breast cancer is highly resistant to chemotherapy, alternative anticancer strategies have been developed.
In particular, many studies have demonstrated that curcumin, a derivative of turmeric, can be used as natural agent in treatment of some types of cancer by playing antiproliferative and antioxidant effects.
In our study, we assessed the antitumor activities of curcumin in ER-negative human breast cancer cell line resistant to chemotherapy, MDA.MB231 by in vitro and in vivo experiments.
In vitro data allowed us to demonstrate that curcumin played a role in regulation of proliferation and apoptosis in MDA.MB231 cells.
In vivo, by generation of mouse model of breast cancer, we showed that treatment of curcumin inhibited tumor growth and angiogenesis.
Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-κB.
Our data demonstrated that curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.
American Psychological Association (APA)
Bimonte, Sabrina& Barbieri, Antonio& Palma, Giuseppe& Rea, Domenica& Luciano, Antonio& D'Aiuto, Massimiliano…[et al.]. 2015. Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057115
Modern Language Association (MLA)
Bimonte, Sabrina…[et al.]. Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057115
American Medical Association (AMA)
Bimonte, Sabrina& Barbieri, Antonio& Palma, Giuseppe& Rea, Domenica& Luciano, Antonio& D'Aiuto, Massimiliano…[et al.]. Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057115