Blood Vessel Matrix Seeded with Cells: A Better Alternative for Abdominal Wall Reconstruction—A Long-Term Study
Joint Authors
Kucharzewski, Marek
Bodnar, Magdalena
Marszalek, Andrzej
Kotela, Andrzej
Kotela, Ireneusz
Pokrywczynska, Marta
Nowacki, Maciej
Jundziłł, Arkadiusz
Nazarewski, Łukasz
Kloskowski, Tomasz
Skopińska-Wisniewska, Joanna
Łukasiewicz, Aleksander
Nazarewski, Sławomir
Drewa, Tomasz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The aim of this study was to present abdominal wall reconstruction using a porcine vascular graft seeded with MSC (mesenchymal stem cells) on rat model.
Material and Methods.
Abdominal wall defect was prepared in 21 Wistar rats.
Acellular porcine-vascular grafts taken from aorta and prepared with Triton X were used.
14 aortic grafts were implanted in place, of which 7 grafts were seeded with rat MSC cells (Group I), and 7 were acellular grafts (Group II).
As a control, 7 standard polypropylene meshes were used for defect augmentation (Group III).
The assessment method was performed by HE and CD31 staining after 6 months.
The mechanical properties have been investigated by Zwick&Roell Z0.5.
Results.
The strongest angiogenesis and lowest inflammatory response were observed in Group I.
Average capillaries density was 2.75, 0.75, and 1.53 and inflammatory effect was 0.29, 1.39, and 2.72 for Groups I, II, and III, respectively.
The means of mechanical properties were 12.74±1.48, 7.27±1.56, and 14.4±3.7 N/cm in Groups I and II and control, respectively.
Conclusions.
Cell-seeded grafts have better mechanical properties than acellular grafts but worse than polypropylene mesh.
Cells improved mechanical and physiological properties of decellularized natural scaffolds.
American Psychological Association (APA)
Nowacki, Maciej& Jundziłł, Arkadiusz& Nazarewski, Łukasz& Kotela, Andrzej& Kloskowski, Tomasz& Skopińska-Wisniewska, Joanna…[et al.]. 2015. Blood Vessel Matrix Seeded with Cells: A Better Alternative for Abdominal Wall Reconstruction—A Long-Term Study. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057123
Modern Language Association (MLA)
Nowacki, Maciej…[et al.]. Blood Vessel Matrix Seeded with Cells: A Better Alternative for Abdominal Wall Reconstruction—A Long-Term Study. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1057123
American Medical Association (AMA)
Nowacki, Maciej& Jundziłł, Arkadiusz& Nazarewski, Łukasz& Kotela, Andrzej& Kloskowski, Tomasz& Skopińska-Wisniewska, Joanna…[et al.]. Blood Vessel Matrix Seeded with Cells: A Better Alternative for Abdominal Wall Reconstruction—A Long-Term Study. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1057123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057123