New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells
Joint Authors
Kayumov, Airat R.
Nureeva, Aliya A.
Trizna, Elena Yu.
Gazizova, Guzel R.
Bogachev, Mikhail I.
Shtyrlin, Nikita V.
Pugachev, Mikhail V.
Sapozhnikov, Sergey V.
Shtyrlin, Yurii G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on tissues and inorganic surfaces.
In the biofilm bacterial cells are embedded in a self-produced polysaccharide matrix and thereby are inaccessible to biocides, antibiotics, or host immune system.
Here we show the antibacterial activity of newly synthesized cationic biocides, the quaternary ammonium, and bisphosphonium salts of pyridoxine (vitamin B6) against biofilm-embedded Staphylococci.
The derivatives of 6-hydroxymethylpyridoxine were ineffective against biofilm-embedded S.
aureus and S.
epidermidis at concentrations up to 64 μg/mL, although all compounds tested exhibited low MICs (2 μg/mL) against planktonic cells.
In contrast, the quaternary ammonium salt of pyridoxine (N,N-dimethyl-N-((2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl)octadecan-1-aminium chloride (3)) demonstrated high biocidal activity against both planktonic and biofilm-embedded bacteria.
Thus, the complete death of biofilm-embedded S.
aureus and S.
epidermidis cells was obtained at concentrations of 64 and 16 μg/mL, respectively.
We suggest that the quaternary ammonium salts of pyridoxine are perspective to design new synthetic antibiotics and disinfectants for external application against biofilm-embedded cells.
American Psychological Association (APA)
Kayumov, Airat R.& Nureeva, Aliya A.& Trizna, Elena Yu.& Gazizova, Guzel R.& Bogachev, Mikhail I.& Shtyrlin, Nikita V.…[et al.]. 2015. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057124
Modern Language Association (MLA)
Kayumov, Airat R.…[et al.]. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057124
American Medical Association (AMA)
Kayumov, Airat R.& Nureeva, Aliya A.& Trizna, Elena Yu.& Gazizova, Guzel R.& Bogachev, Mikhail I.& Shtyrlin, Nikita V.…[et al.]. New Derivatives of Pyridoxine Exhibit High Antibacterial Activity against Biofilm-Embedded Staphylococcus Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057124