Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status
Joint Authors
Cruz Guzmán, Oriana del Rocío
Escobar Cedillo, Rosa Elena
Rodríguez-Cruz, Maricela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation described in patients with Duchenne muscular dystrophy (DMD) may be related to loss of muscle function or to obesity.
It is unknown if circulating proinflammatory cytokines (IL-6, IL-1, and TNF-α) levels are associated with muscle function.
The purpose was to evaluate whether an association exists between systemic inflammation with muscle function and nutritional status in DMD patients.
In 66 DMD patients without corticosteroid treatment, the following were evaluated in serum: cytokines (IL-1, IL-6, and TNF-α), C-reactive protein (CRP), leptin, adiponectin, and creatine kinase (CK).
Muscle function was evaluated using Vignos Scale.
Patients with better muscle function had the highest concentration of CK, IL-1, and TNF-α compared with less muscle function.
No differences in IL-6 and adiponectin concentration were identified among groups with different levels of muscle function.
Also, no differences were observed in the concentration of cytokines among groups with different nutritional status levels (underweight, normal weight, and overweight/obese).
However, CRP and leptin were increased in the obese group compared with normal and underweight subjects.
Systemic inflammation is increased in patients with better muscle function and decreases in DMD patients with poorer muscle function; nevertheless, systemic inflammation is similar among different levels of nutritional status in DMD patients.
American Psychological Association (APA)
Cruz Guzmán, Oriana del Rocío& Rodríguez-Cruz, Maricela& Escobar Cedillo, Rosa Elena. 2015. Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057131
Modern Language Association (MLA)
Cruz Guzmán, Oriana del Rocío…[et al.]. Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1057131
American Medical Association (AMA)
Cruz Guzmán, Oriana del Rocío& Rodríguez-Cruz, Maricela& Escobar Cedillo, Rosa Elena. Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1057131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057131