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Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan
Joint Authors
Hsu, Ling-I
Wu, Meei-Maan
Lee, Cheng-Yeh
Yang, Tse-Yen
Hsiao, Bo-Yu
Wang, Yuan-Hung
Chen, Chien-Jen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Deficiency in the capability of xenobiotic detoxification and arsenic methylation may be correlated with individual susceptibility to arsenic-related skin cancers.
We hypothesized that glutathione S-transferase (GST M1, T1, and P1), reactive oxygen species (ROS) related metabolic genes (NQO1, EPHX1, and HO-1), and DNA repair genes (XRCC1, XPD, hOGG1, and ATM) together may play a role in arsenic-induced skin carcinogenesis.
We conducted a case-control study consisting of 70 pathologically confirmed skin cancer patients and 210 age and gender matched participants with genotyping of 12 selected polymorphisms.
The skin cancer risks were estimated by odds ratio (OR) and 95% confidence interval (CI) using logistic regression.
EPHX1 Tyr113His, XPD C156A, and GSTT1 null genotypes were associated with skin cancer risk (OR = 2.99, 95% CI = 1.01–8.83; OR = 2.04, 95% CI = 0.99–4.27; OR = 1.74, 95% CI = 1.00–3.02, resp.).
However, none of these polymorphisms showed significant association after considering arsenic exposure status.
Individuals carrying three risk polymorphisms of EPHX1 Tyr113His, XPD C156A, and GSTs presented a 400% increased skin cancer risk when compared to those with less than or equal to one polymorphism.
In conclusion, GSTs, EPHX1, and XPD are potential genetic factors for arsenic-induced skin cancers.
The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.
American Psychological Association (APA)
Hsu, Ling-I& Wu, Meei-Maan& Wang, Yuan-Hung& Lee, Cheng-Yeh& Yang, Tse-Yen& Hsiao, Bo-Yu…[et al.]. 2015. Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057134
Modern Language Association (MLA)
Hsu, Ling-I…[et al.]. Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1057134
American Medical Association (AMA)
Hsu, Ling-I& Wu, Meei-Maan& Wang, Yuan-Hung& Lee, Cheng-Yeh& Yang, Tse-Yen& Hsiao, Bo-Yu…[et al.]. Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1057134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1057134